But they couldn't quite leave their past behind. River was nearly blind. And Daisy had a serious wound on her back that took a long time to heal.
In fact, the only good thing about their past lives was each other. It's a bond that remains unbroken at the shelter.
"They are literally always at each other's sides, and their size difference is no barrier," Gillian Kocher, of the Pennsylvania SPCA, tells The Dodo. "If you take them out and interact with them, you will see right away that they love each other - and people - very much."
And it goes beyond friendship. Daisy and River are each other's caregivers.