Chronically underweight and ravaged by fleas, the dog was left in a crate at the Peaceable Kingdom animal shelter in Whitehall, Pennsylvania, last November.
She weighed around 6 pounds and had open sores all over her body.
"She had severe anemia from the fleas," Peaceable Kingdom's medical director Sarah Donnelly told The Dodo. "They were basically sucking the life out of her."
But Annie would never be orphaned again.
Since undergoing treatment at Peaceable Kingdom - and catching up on all the love she had missed in her life - Annie has rebounded relentlessly.